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KMID : 0361520050160060468
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Korean Journal of Psychopharmacology
2005 Volume.16 No. 6 p.468 ~ p.474
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Effect of Topiramate on Risperidone-Induced Weight Gain : A Pilot Study
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정문용/Chung MY
전은미/정지영/이태영/Cheon EM/Jung JY/Lee TY
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Abstract
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Objective : It is known that risperidone induces weight gain moderately which has been previously considered of little clinical concern. And there was no specific effective treatment for atypical antipsychotics-induced weight gain. The study was performed to evaluate the effectiveness of topiramate as an weight-reducing medicine for schizophrenia patients with risperidone-induced weight gain.
Methods : Topiramate, 100-200 mg/day, was administered to 12 schizophrenia patients with risperidone-induced weight gain. Body weight and body mass index (BMI) were measured at baseline, 4-week and 8-week. Brief Psychatric Rating Scale (BPRS) and Positive And Negative Syndrome Scale (PANSS) were used to evaluate psychotic symptoms.
Results : Body weight and BMI were decreased significantly at 4-week and 8-week treatment compared to baseline (weight loss：1.17±1.80 kg and 2.50±2.24 kg ; BMI : -0.41±0.65 kg/㎡ and -0.88±0.82 kg/㎡ on 4-week and 8-week). Psychiatric symptoms were improved significantly in BPRS and PANSS. Adverse effects were showed such as fatigue, paresthesia, difficulty in concentration and diarrhea, which were mild and self-limited.
Conclusion : It is suggested that topiramate have significant effects on patients with risperidone-induced weight gain. Randomized controlled study would be necessary in the near future.
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